Papers
Early glymphatic failure in AppNL-F knock-in mice is linked to parenchymal border macrophages loss
Na Liu, Yiyi Yang, Marios Kritsilis, Kelley M Swanberg, Chenchen Liu, Xuanhui Liu, Brecht Moonen, Tomas Deierborg, Per Nilsson, Stina Syvänen, Dag Sehlin, Iben Lundgaard
Repeated moderate hypothermia leads to sustained glymphatic dysfunction and loss of vascular AQP4 polarization
Chenchen Liu, Na Liu, Nagesh C Shanbhag, Marios Kritsilis, Nicholas Burdon Bèchet, Jari Jukkola, Ahmed M Eltanahy, Roberta Battistella, Iben Lundgaard
1H-MRS-visible brain lactate dynamics are perturbed in Aqp4-knockout mouse models of disrupted cerebrospinal fluid flow
Jari Jukkola, Maryam Hassan Ismaiel Hassan, Michael Gottschalk, Iben Lundgaard, Kelley M Swanberg
Multi-Modal MRI Mouse Brain Extraction Using Template-Based Diffeomorphic Registration
Kay C Igwe, Maryam Hassan Ismaiel Hassan, Jari Jukkola, Zongyu Li, Taisheng Wu, Jia Guo, Iben Lundgaard, Kelley M Swanberg
Evidence-based denoising optimization for accurate GABA estimation by 14.1-tesla 13C-MRS
Kelley M Swanberg, Iben Lundgaard, Joao Duarte
Resolving the mysteries of brain clearance and immune surveillance
Jonathan Kipnis, Helene Benveniste, Anne Eichmann, Jean-Leon Thomas, Daniel S Reich, Laura D Lewis, Li-Huei Tsai, Antoine Drieu, Erik NTP Bakker, Douglas H Kelley, Iben Lundgaard, Humberto Mestre, Benedikt Zott, Per Kristian Eide, Matthias JP van Osch, Su
Global metabolomics profiling of glucuronides in human plasma, fecal, and cerebrospinal fluid samples
Ioanna Tsiara, Mario SP Correia, Fan Yang, Weiming Zeng, Pauline Seeburger, Belén Hervás Povo, Iben Lundgaard, Manuel Menéndez-González, Miroslav Vujasinovic, J-Matthias Löhr, Daniel Globisch
Loss of glymphatic homeostasis in heart failure
Marios Kritsilis, Lotte Vanherle, Marko Rosenholm, René in ‘t Zandt, Yuan Yao, Kelley M Swanberg, Pia Weikop, Michael Gottschalk, Nagesh C Shanbhag, Jiebo Luo, Kimberly Boster, Maiken Nedergaard, Anja Meissner, Iben Lundgaard
High-field contrast-enhanced magnetic resonance imaging demonstrates cerebrospinal fluid nasal efflux dynamics in vivo
Kelley M Swanberg, Marios Kritsilis, Nagesh Shanbhag, Emily Johansson, Jari Jukkola, René In ‘t Zandt, and Iben Lundgaard
Extracellular vesicles released from microglia after palmitate exposure impact brain function
Gabriela C De Paula, Blanca I Aldana, Roberta Battistella, Rosalía Fernández-Calle, Andreas Bjure, Iben Lundgaard, Tomas Deierborg, João MN Duarte
Identification of new ketamine metabolites and their detailed distribution in the mammalian brain
Theodosia Vallianatou, Carina de Souza Anselmo, Ioanna Tsiara, Nicholas B Bèchet, Iben Lundgaard, Daniel Globisch
Cerebrospinal fluid pathways are perturbed in aging and prodromal Alzheimer’s disease
Tekla Maria Kylkilahti, Max Wictor, David Berron, Johannes Töger, Karin Markenroth Bloch, Niklas Mattson-Carlgren, Oskar Hansson, Iben Lundgaard
Anionic nanoplastic contaminants promote Parkinson’s disease–associated α-synuclein aggregation
Zhiyong Liu, Arpine Sokratian, Addison M Duda, Enquan Xu, Christina Stanhope, Amber Fu, Samuel Strader, Huizhong Li, Yuan Yuan, Benjamin G Bobay, Joana Sipe, Ketty Bai, Iben Lundgaard, Na Liu, Belinda Hernandez, Catherine Bowes Rickman, Sara E Miller, And
Caffeine acutely reduces aqueductal CSF flow in humans
Tekla Maria Kylkilahti, Max Wictor, Johannes Töger, Karin Markenroth Bloch, Iben Lundgaard
Mapping of neuroinflammation-induced hypoxia in the spinal cord using optoacoustic imaging
Marta Ramos-Vega, Pontus Kjellman, Mihail Ivilinov Todorov, Tekla Maria Kylkilahti, B Thomas Bäckström, Ali Ertürk, Chris Denis Madsen, Iben Lundgaard
The glymphatic system: Current understanding and modeling
Tomas Bohr, Poul G Hjorth, Sebastian C Holst, Sabina Hrabětová, Vesa Kiviniemi, Tuomas Lilius, Iben Lundgaard, Kent-Andre Mardal, Erik A Martens, Yuki Mori, U Valentin Nägerl, Charles Nicholson, Allen Tannenbaum, John H Thomas, Jeffrey Tithof, Helene Ben
Extracellular vesicles from palmitate-exposed microglia trigger brain dysfunction in mice
Gabriela Cristina De Paula, Rosalia F Calle, Tomas Deierborg, Daria Rago, Roberta Battistella, Iben Lundgaard, Joao Duarte
Real‐time imaging of respiratory effects on cerebrospinal fluid flow in small diameter passageways
Johannes Töger, Mads Andersen, Olle Haglund, Tekla Maria Kylkilahti, Iben Lundgaard, Karin Markenroth Bloch
A clinical primer for the glymphatic system
Lucas P Carlstrom, Ahmed Eltanahy, Avital Perry, Alejandro A Rabinstein, Benjamin D Elder, Jonathan M Morris, Fredric B Meyer, Christopher S Graffeo, Iben Lundgaard, Terry C Burns
Sleep, cerebrospinal fluid, and the glymphatic system: A systematic review
Pearlynne LH Chong, Dea Garic, Mark D Shen, Iben Lundgaard, Amy J Schwichtenberg
Regional brain analysis of modified amino acids and dipeptides during the sleep/wake cycle
Theodosia Vallianatou, Nicholas B Bechet, Mario SP Correia, Iben Lundgaard, Daniel Globisch
Differential regulation of oxidative stress, microbiota-derived, and energy metabolites in the mouse brain during sleep
Theodosia Vallianatou, Weifeng Lin, Nicholas B Bechet, Mario SP Correia, Nagesh C Shanbhag, Iben Lundgaard, Daniel Globisch
Impaired cerebrospinal fluid transport due to idiopathic subdural hematoma in pig: an unusual case
Nagesh C Shanbhag, Nicholas Burdon Bèchet, Marios Kritsilis, Iben Lundgaard
Not all lectins are equally suitable for labeling rodent vasculature
Roberta Battistella, Marios Kritsilis, Hana Matuskova, Douglas Haswell, Anne Xiaoan Cheng, Anja Meissner, Maiken Nedergaard, Iben Lundgaard
DNase treatment prevents cerebrospinal fluid block in early experimental pneumococcal meningitis
Chiara Pavan, Anna LR Xavier, Marta Ramos, Jane Fisher, Marios Kritsilis, Adam Linder, Peter Bentzer, Maiken Nedergaard, Iben Lundgaard
Achieving brain clearance and preventing neurodegenerative diseases-A glymphatic perspective
Kylkilahti TM, Berends E, Ramos M, Shanbhag NC, Töger J, Markenroth Bloch K, Lundgaard I.
A functional observational battery for evaluation of neurological outcomes in a rat model of acute bacterial meningitis
Fisher J, Pavan C, Ohlmeier LS, Nilson B, Lundgaard I, Linder A, Bentzer P.
Light sheet fluorescence microscopy of optically cleared brains for studying the glymphatic system
Bèchet NB, Kylkilahti TM, Mattsson B, Petrasova M, Shanbhag NC, Lundgaard I.
Glymphatic System Impairment in Alzheimer’s Disease and Idiopathic Normal Pressure Hydrocephalus
Reeves BC, Karimy JK, Kundishora AJ, Mestre H, Cerci HM, Matouk C, Alper SL, Lundgaard I, Nedergaard M, Kahle KT.
Neutrophil extracellular traps in the central nervous system: a novel therapeutic target in pneumococcal meningitis
Mohanty T, Fisher J, Bakochi A, Neumann A, Cardoso J, Karlsson C, Pavan C, Lundgaard I, Nilson B, Reinstrup P, Bonnevier J, Cederberg D, Malmström J, Bentzer P, Linder A.
PDGF-B Is Required for the Development of the Glymphatic System
Munk AM, Wang W, Bèchet NB, Cheng AX, Eltanahy A, Sigurdsson B, Benraiss A, Mäe MA, Kress BT, Kelley DH, Betsholtz C, Møllgård K, Meissner A, Nedergaard M, Lundgaard I.
Cisterna Magna Injection in Rats to Study Glymphatic Function
Ramos R, Bèchet NB, Battistella R, Pavan C, Xavier ALR, Nedergaard M, Lundgaard I.
Methods Mol Biol. 1938:97-104
Transcranial optical imaging reveals a pathway for optimizing the delivery of immunotherapeutics to the brain
Plog B, Mestre H, Olveda G, Sweeney A, Kenney HM, Cove A, Dholakia K, Titho J, Nevins T, Lundgaard I, Du T, Kelley D, Nedergaard M.
Cannula Implantation into the Cisterna Magna of Rodents
Xavier A, Hauglund N, von Holstein-Rathlou S, Li Q, Sanggaard S, Lou N, Lundgaard I, Nedergaard M
2018
Beneficial effects of low alcohol exposure, but adverse effects of high alcohol intake on glymphatic function
Lundgaard I, Wang W, Eberhardt A, Vinitksy H, Reeves B, Peng S, Lou N, Hussain R, Nedergaard M.